Five years after the Los Angeles events, Dominic Toretto (
Vin Diesel) and his new crew: Leticia "Letty" Ortiz (
Michelle Rodriguez), Leo Tego (
Tego Calderón), Omar Santos (
Don Omar), Cara Mirtha (
Mirtha Michelle) and Han Seoul-Oh (
Sung Kang), are hijacking fuel tankers in the
Dominican Republicdue to his old crew with Leon, Jesse (killed by Johnny Tran), Vince (got wounded and escaped to Rio) and Leticia already disbanded from the
first movie. Dominic begins to suspect the trail is too hot and leaves Letty to go elsewhere to avoid being caught. Some time later, In
Panama City, Dominic gets a call from his sister, Mia Toretto (
Jordana Brewster), who tells him that Letty has been murdered after getting into a near fatal car accident. Dominic heads back to
Los Angeles to examine Letty's crash and finds traces of
nitromethane. He then goes to the only car mechanic that uses nitromethane and coerces him into giving him the name David Park (
Ron Yuan), the man who ordered the fuel.
Meanwhile,
F.B.I. agent Brian O'Conner (
Paul Walker) is trying to track down a drug dealer named Arturo Braga . His search leads him to David Park. Dominic arrives at Park's apartment first and hangs him out of the window by his ankles before letting go. Brian, who was also on his way to Park's place, saves Park, but Dominic escapes and Park becomes the FBI's new informant. Park gets Brian into a
street race through Los Angeles organized by Ramon Campos (
John Ortiz) Braga's right hand. The winner will become the last driver on a team that traffics
heroin between the
United States-Mexico border. Brian selects a
Nissan Skyline GT-R R34 modified for better drifts due to
RWD using from the Impound Lot. Dominic also shows up to race in his modified
1970 Chevrolet Chevelle. Dominic wins by bumping Brian's car, making him lose control. Brian uses his position as an FBI agent to arrest another driver, Dwight Mueller (
Greg Cipes), and takes his place on the team.