Hollow Man 2

At a plush cocktail party at Reisner Institute, a government think tank based in Redmond, Washington, the guests and scientists present are enjoying themselves. One such scientist, Dylan, suddenly is manipulated by an invisible force, which drags the scientist into the nearby bathroom and proceeds to brutally beat and throw Dylan around the room. Dylan apparently knows who it is, and begs the invisible man not to kill him, as he "doesn't have it", but the invisible man persists as he's "getting worse" and he's "running out of time". Though he does not know how to make more, Dylan mentions that another scientist, Maggie Dalton, knows the formula. Seemingly accepting this, the invisible man releases Dylan and tells him not to tell anyone he was here, to which he agrees. No sooner has he left, than Dylan attempts to call someone on his cell phone, but the invisible man, who only pretended to leave to see if Dylan would stay silent, smashes the phone on the ground, and slashes Dylan's neck with the broken circuit board, killing him.

The police arrive at the laboratory to conduct an investigation, but the military supervisor of the laboratory, Colonel Gavin Bishop, insists it is an internal military situation and the police have no jurisdiction over the crime, and refuses to relent even when one of the detectives, Frank Turner, points out that they have no experience conducting a proper criminal investigation.

Fearing an attack on the remaining scientists, the lab company owner, Dr. William Reisner, employs Turner and his partner, Detective Lisa Martinez, to protect Maggie (despite the military forcing the police out of the investigation), but refuses to divulge any information to the detectives on the nature of the work they are doing, which includes refusing to tell them that an invisible killer is on the loose.

Turner and Lisa, after gaining Maggie's reluctant cooperation, stand guard outside of Maggie's house. The invisible man watches from a nearby bedroom window where a teenage couple are working on a home sex video. Spotted by the night vision camera, he leaves the room and heads outside. When Lisa opens the door to let the cat in, the invisible man takes advantage of the distraction to sneak past Lisa into the house. Just as the invisible man reaches the study where Maggie is working, Lisa, having sensed something wrong, traces the source to the invisible man, who uses a lamp's wire to throttle her. Maggie and Turner promptly race to Lisa's aid, but it is too late.

Suddenly, a large battalion of military commandos appears and storms the house, grabbing Turner and Maggie, and use night vision cameras and weapons to target and corner the invisible man inside the study. Outside, Turner confronts Bishop, as he has realized that he and Lisa were nothing more than pawns, to lure the invisible man to the house where the commandos were to terminate him to prevent the lab's work being exposed. Suddenly, several stun grenades are set off by the invisible man around the house, blinding the commando's sensors and, combined with his own invisibility, the man escapes in pursuit of Turner and Maggie. Closely pursued, Turner and Maggie force their way down a crowded street and run across a busy road. The man is poised to catch up to them, but a speeding car strikes the man. Badly injured, the man reluctantly retreats to his abandoned apartment and injects himself with a mysterious blue liquid that disguises his now-visible wounds.

Maggie is taken into protective custody by the police, where Frank's superior and friend, Captain Tom Harrison, though sympathetic with Turner's desire for revenge, has received "higher orders" to have Maggie transferred to military custody and then intends to let the case go. Disgusted with his friend's attitude, especially when he knows Tom knows who the invisible man was, Frank helps Maggie escape from the police stations and, after stealing a car, flees with her. When safe, Turner demands to know about the invisible man for the purpose of avenging Lisa's death.

Meanwhile, Bishop and Reisner, knowing their work and careers would end if Maggie talks, make Turner into a fugitive.

• Christian Slater as Michael Griffin/Hollow Man
• Peter Facinelli as Det. Frank Turner/the second Hollow Man. A detective situated in Redmond, Washington, he was first seen conducting an investigation at Dylan's demise
• Laura Regan as Dr. Maggie Dalton
• David McIlwraith as Dr. William Reisner. The primary antagonist. A brilliant but corrupt molecular biologist responsible for re-creating Sebastian Caine's invisibility formula from the previous movie. Met his end when Turner tricked him in the way of a speeding car
• William MacDonald as Col. Gavin Bishop
• Sarah Deakins as Det. Lisa Martinez
• Jessica Harmon as Heather Dalton
• Chelah Horsdal as Blind Secretary
• Sonya Salomaa as Trophy Wife
• Terri Anne Welyki as Pearl Girl
• John Shaw as Dr. Devin Villiers
• Mike Dopud as Officer Chesley